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Semaglutide is a drug that is similar to incretin, a natural hormone in the body that helps control blood sugar, insulin levels and digestion. Semaglutide may be used with proper diet and exercise to control high blood sugar levels in adults with type 2 diabetes. It may also be used by adults with type 2 diabetes and heart disease to lower the risk of death from a heart attack or stroke. Additionally, a 2021 study praised semaglutide as a "game-changer" drug to treat obesity after trial showed that obese participants taking semaglutide, in addition to a lifestyle intervention, lost on average 14.9% of their body weight.